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KMID : 1137820170380050271
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의공학회지
2017 Volume.38 No. 5 p.271 ~ p.276
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A Panel of Serum Biomarkers for Diagnosis of Prostate Cancer
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Cho Jung-Ki
Kim Young-Hee
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Abstract
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Cancer biomarkers are using in the diagnosis, staging, prognosis and prediction of disease progression. But, there are not sufficiently profiled and validated in early detection and risk classification of prostate cancer. In this study, we have devoted to finding a panel of serum biomarkers that are able to detect the diagnosis of prostate cancer. The serum samples were consisted of 111 prostate cancer and 343 control samples and examined. Eleven biomarkers were constructed in this study, and then nine biomarkers were relevant to candidate biomarkers by using t test. Finally, four biomarkers, PSA, ApoA2, CYFRA21.1 and TTR, were selected as the prostate cancer biomarker panel, logistic regression was used to identify algorithms for diagnostic biomarker combinations(AUC = 0.9697). A panel of combination biomarkers is less invasive and could supplement clinical diagnostic accuracy.
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KEYWORD
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Serum biomarker , Prostate cancer , algorithm
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